Jasmine Carter, M.A.

Research Description

Jasmine has used her background in stem cell biology to develop iPSC-derived neuronal models and translate them into tools to better understand the underlying molecular mechanisms associated with ID. She has focused on elucidating the synaptic plasticity impairments associated ID. She utilizes molecular and omics-based approaches in patient-derived induced pluripotent stem cells (iPSCs), neural stem cells (NSCs) and neurons to elucidate the consequence of genetic variants on the phospho-proteome and transcriptome in a neurodevelopmentally relevant manner. Using the first human cellular models for Jordan’s syndrome developed in the Fink lab, Jasmine has discovered that there are dysregulated PP2A/ PPP2R5D targets at the transcript and protein level and she is expanding the utility of these patient-derived models by employing novel strategies for correcting pathogenic nucleotides associated with ID via a CRISPR/RNA editing strategy in NSCs. The ultimate goal of this research is to better understand the neuronal disease pathology associated with ID and use editing technologies for rescue