Kelley Patten, M.P.H., Ph.D.

Kelley Patten

Position Title
Discovery Safety Scientist, Astra Zeneca

  • Pharmacology & Toxicology Graduate Group
  • Major Professor: Pamela Lein

Research Description

Kelley’s LaMP research focused on characterizing the effect of traffic-related air pollution (TRAP) on the developing and aging brain. Her work involved chronic exposure of transgenic and wildtype rats to ambient TRAP collected from a highway tunnel and delivered in real-time to animals housed in an adjacent vivarium. Neuropathologic and behavioral effects were monitored over time. Kelley’s research was significant in that it demonstrated that human-relevant exposures to TRAP increase the expression of phenotypes relevant to neurodevelopmental disorders and Alzheimer’s disease (AD), even in wildtype rats. These are the first preclinical data to validate the human epidemiological data and confirm that TRAP is an important environmental risk factor for brain disease. Her data also supported the hypothesis that TRAP effects on AD phenotypes are mediated, in part, by neuroinflammation. One of her first-author publications describing this work (Patten et al. 2020, Transl Psych) was selected at an NIEHS Extramural Paper of the month of July 2020; this same paper was highlighted in multiple media outlets, including: MSN, Yahoo! News, The Guardian, Environmental News Network, Technology Networks, The Medical News, Green Car Congress, Medical Xpress, ScienMag, Science Daily, Daily Democrat, and EurkAlert!.

Education and Degree(s)
  • B.S. in Biological Sciences from UC Davis -2010
  • M.P.H. in Public Health-Epidemiology from UC Berkeley -2016
  • Ph.D. in Pharmacology and Toxicology -2020
Honors and Awards
  • 1st place, Toshio Narahashi Graduate Student Poster Competition, Society of Toxicology (SOT) Neurotoxicology Specialty Section-2020
  • David Ray Award for Best Oral Presentation, International Neurotoxicology Association -2019
  • Conference Travel Award, International Society for Neurochemistry -2019
  • Best Poster Award, UC Davis Alzheimer’s Disease Center Symposium -2019
  • Learning, Memory and Plasticity (LaMP) Training Grant 2017-2018
  • Patten KT, Valenzuela AE, Wallis C, Berg EL, Silverman JL, Bein KJ, Wexler AS, Lein PJ, 2021, The effects of chronic exposure to ambient traffic-related air pollution on Alzheimer’s disease phenotypes in wildtype and genetically predisposed male and female rats. Environmental Health Perspectives
  • Edwards S, Zhao G, Tran J, Patten KT, Valenzuela A, Wallis C, Bein KJ, Wexler AS, Lein PJ and Rao X, 2020, Pathological Cardiopulmonary Evaluation of Rats Chronically Exposed to Traffic-Related Air Pollution. Environmental health perspectives, 128:127003. PMCID: PMC7717845
  • Berg EL, Pedersen LR, Pride MC, Petkova SP, Patten KT, Valenzuela AE, Wallis C, Bein KJ, Wexler A, Lein PJ and Silverman JL, 2020, Developmental exposure to near roadway pollution produces behavioral phenotypes relevant to neurodevelopmental disorders in juvenile rats. Translational psychiatry, 10:289. PMCID: PMC7431542
  • Patten KT, González EA, Valenzuela A, Berg E, Wallis C, Garbow JR, Silverman JL, Bein KJ, Wexler AS and Lein PJ, 2020, Effects of early life exposure to traffic-related air pollution on brain development in juvenile Sprague-Dawley rats. Translational psychiatry, 10:166. PMCID: PMC7264203
  • Patten KT and Lein PJ, 2019, Gene-environment interactions determine risk for dementia: the influence of lifestyle on genetic risk for dementia. Annals of translational medicine, 7:S322. PMCID: PMC6976405